NAD+

Essential coenzyme involved in cellular energy metabolism, DNA repair, and sirtuin signaling. NAD+ levels decline significantly with age. Direct injection bypasses oral bioavailability limitations of NAD+ precursors like NMN and NR.

Dose / vial

100 mg/mL · 1000 mg per 10mL vial

Purity

99.5% HPLC

Route

Subcutaneous or IM per clinician protocol

Half-life

Variable tissue uptake-dependent

$325 USD / vial

Signed by a licensed physician before shipment

Third-party COA available per lot

Cold-chain shipping, discreet packaging

— §01 Peptide breakdown

What's in the vial, precisely.

Active · Coenzyme (β-nicotinamide adenine dinucleotide)

NAD+ (Nicotinamide Adenine Dinucleotide)

Essential coenzyme present in every cell, central to cellular energy metabolism, DNA repair, and sirtuin signaling. NAD+ exists in equilibrium with its reduced form (NADH) and serves as substrate for the sirtuin family of longevity regulators (SIRT1-7) and the PARP family of DNA repair enzymes. Cellular NAD+ levels decline significantly with age.

MW · 663.4 g/mol1000 mg per 10mL vial

Buffer · pH control

Acetate buffer

Maintains reconstituted solution at pH 5.0–5.5 — the range in which the peptide is most chemically stable. Degrades to water and acetate; renally cleared.

pH 5.0 – 5.5q.s.

Excipient · Stabilizer

Mannitol

USP-grade bulking agent used during lyophilization. Produces a uniform cake, prevents peptide collapse during reconstitution, and has no pharmacologic activity at the doses used.

Pharmacopeial5 mg / vial

— §02 Mechanism of action

How it works in the body.

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme present in every living cell. It serves as the central electron carrier in cellular respiration, the substrate for sirtuins and PARPs (key regulators of longevity-associated cellular processes), and a co-factor for hundreds of metabolic enzymes. NAD+ levels decline significantly with age — by some estimates, by 50% or more between ages 40 and 60.

Direct NAD+ delivery bypasses the bioavailability limitations of oral NAD+ precursors (NMN, NR), which require multiple metabolic conversion steps before becoming usable cellular NAD+. Subcutaneous and IM delivery achieve more direct cellular uptake, though the peptide community continues to debate optimal delivery routes (IV, IM, SC, or oral precursors).

The compound provided here is not FDA-approved as a therapeutic product. Elite HRT's clinicians determine appropriateness based on individual patient assessment.

Cellular energy metabolism

NAD+ is the central electron carrier in cellular respiration. It accepts electrons during glycolysis, the citric acid cycle, and beta-oxidation, becoming NADH. NADH then donates these electrons to the electron transport chain, driving ATP production. Adequate NAD+ availability is rate-limiting for mitochondrial energy output.

Sirtuin activation

NAD+ is the obligatory cofactor for the sirtuin family (SIRT1-7) — protein deacetylases that regulate cellular stress response, mitochondrial biogenesis, gene expression, and DNA repair. Sirtuin activity is rate-limited by NAD+ availability; declining NAD+ with age is one of the proposed mechanisms by which sirtuin function decreases over time.

DNA repair (PARP cofactor)

Poly(ADP-ribose) polymerases (PARPs) consume NAD+ during DNA damage response. Adequate NAD+ supports the PARP-mediated repair of DNA strand breaks. Chronic high PARP activity (from accumulated DNA damage, inflammation, or oxidative stress) can deplete cellular NAD+ — creating a feedback loop where damage accumulates and repair capacity declines.

Cellular redox balance

The NAD+/NADH ratio is a central indicator of cellular redox state. Maintaining adequate NAD+ supports proper redox balance, which influences hundreds of metabolic enzymes. Chronic redox imbalance is associated with mitochondrial dysfunction, oxidative stress, and many age-related metabolic conditions.

NAD+

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$325