Acetate buffer
Maintains reconstituted solution at pH 5.0–5.5 — the range in which the peptide is most chemically stable. Degrades to water and acetate; renally cleared.
pH 5.0 – 5.5q.s.
Rx OnlyPeptides
Mitochondrial-derived peptide encoded within the mitochondrial genome itself. Discovered in 2015. Modulates metabolic homeostasis, exercise capacity, and insulin sensitivity through pathways that bridge mitochondrial and nuclear function — distinct from most other peptide therapeutics.
At a glance:
- 2 mg/mL · 10 mg per 5mL vial
- 99.0% HPLC
- Subcutaneous bacteriostatic water — pre-mixed
- ~ 2 hr plasma
- Acetate buffer — q.s.
- Mannitol — 5 mg / vial
- MOTS-C — 10 mg per 5mL vial
Precision inside a bottle.
Mannitol
USP-grade bulking agent used during lyophilization. Produces a uniform cake, prevents peptide collapse during reconstitution, and has no pharmacologic activity at the doses used.
Pharmacopeial5 mg / vial
MOTS-C
16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — making it one of the few human peptides not encoded in the nuclear genome. Discovered in 2015 and characterized as an exercise-mimetic and metabolic regulator. Acts primarily through AMPK pathway activation and direct nuclear gene expression effects during metabolic stress.
MW · 2174.5 g/mol10 mg per 5mL vial
MOTS-C in action.
01
AMPK pathway activation
MOTS-C activates AMP-activated protein kinase (AMPK) — the central cellular energy sensor that responds to low ATP states. AMPK activation promotes glucose uptake into cells, increases fatty acid oxidation, and stimulates mitochondrial biogenesis. The same pathway is activated by exercise and metformin, leading to MOTS-C being characterized as an "exercise mimetic."
02
Insulin sensitivity & glucose homeostasis
Through AMPK and downstream effects, MOTS-C improves insulin sensitivity in skeletal muscle and adipose tissue in animal models. Effects on glucose disposal and post-prandial glucose response have been documented in preclinical studies and small pilot human trials. Most relevant in metabolic syndrome contexts and age-related insulin resistance.
03
Exercise capacity & mitochondrial biogenesis
MOTS-C levels naturally increase with exercise. Supplementing the peptide may amplify exercise-induced mitochondrial biogenesis and improve metabolic flexibility. Animal studies show enhanced exercise capacity, improved metabolic response to exercise, and increased mitochondrial density in muscle tissue with MOTS-C administration.
04
Nuclear gene expression effects
Distinct from most peptides, MOTS-C translocates to the cell nucleus during metabolic stress and directly affects gene expression — particularly genes involved in metabolic adaptation. This dual mitochondrial-nuclear signaling role is unusual among peptides and is an active area of research. The mechanism explains some of MOTS-C's broader systemic metabolic effects.
Reviews
“I've been with elite for 6 months and I still can't believe how better I feel everyday. These peptides feel like a cheat code to life.”
“Bespoke formulations takes the worry away from making sure what im getting is legit. It's genuinely a great feeling knowing that what im using will work specifically for me.”
“You know something is different when your doctor knows you by name. I've never felt so connected with my health and my caregiver before and its honestly liberating!”
“Since getting on NAD+ I've been a vocal advocate for its uses for longevity. I was a skeptic too until I discovered elite. The onboarding, the team, the way everything feels so catered to me definitely took the stress out of trying something new.”
“Joining Elite has transformed my life in just six months. These peptides have become my secret weapon for vitality and wellness!”
